Abstracts of Oral Presentations of Mass Spectrometry CVG Annual Symposium:
Click Each Presentation below to view the abstract:
Presentation No. 1 - Accurate and Sensitive All-Ions Quantitation Using a New Ultra High Resolution LCMS and its Application to Endogenous Metabolite Profiling
Mark Sanders1; Kevin J. Mchale1; Chunang (christine) Gu2; Petia Shipkova3
1Thermo Fisher Scientific, Somerset , NJ; 2ThermoFisher Scientific, San Jose, CA; 3Bristol Myers Squibb, Princeton, NJ
Novel Aspect: Accurate and sensitive multi-component quantitation achieved by utililizing high resolution accurate mass LC/MS data
Presentation No. 2 - Dioxin Analysis by Gas Chromatography-Fourier Transform Mass Spectrometry
Vincent Y. Taguchi1; Ray E. Clement1; Stefan Krolik3; Robert Nieckarz1,2; Robert Williams4
1Ministry of the Environment, Toronto, ON; 2University of Waterloo, Waterloo, Canada; 3Consultant to Varian Inc, Montreal, Canada; 4Varian Inc, Lake Forest, CA
Novel Aspect: GC-FTMS analysis of brominated- and chlorinated-dioxins at ultrahigh resolution
Presentation No. 3 - Quantitation of several antiretroviral drugs in human plasma by LC tandem MS
David W. Blank; Brian J. Gilfix; Marcos DiFalco; Line Roy; Bernard F. Gibbs
McGill University, Montreal, QC, Canada
Novel Aspect: Identification and quantitation of several HIV antiretroviral drugs in body fluids
Presentation No. 4 - Improved detection of reactive drug metabolites with bromine-containing glutathione analog using mass defect and isotope pattern matching
Lekha Sleno; Andre LeBlanc; Tze Chieh Shiao; Rene Roy
UQAM, Montreal, Canada
Presentation No. 5 - Rapid analysis of catecholamines and metanephrines in biological fluids by automated online solid-phase extraction LC/MS/MS
Sylvie Beaudet1; Martin Sibum2; Luce Boulanger3
1MDS Analytical Technologies, Concord , Canada ; 2Spark Holland Inc., Emmen, NETHERLANDS; 3CHUM St-Luc Hospital, Montreal, Canada
Novel Aspect: This high-throughput SPE/LC/MS/MS method enables automatic extraction, concentration and separation of plasma catecholamines in a very short analysis time.
Presentation No. 6 - Aqueous-Normal Phase/HILIC in LC-MS Separations: Retention Mechanisms and Their Impact on Retention and Selectivity
David S. Bell, Carmen T. Santasania and Craig R. Aurand
Sigma-Aldrich/Supelco - 595 N. Harrison Rd. Bellefonte, PA, USA
Presentation No. 7 - High-Field MALDI FTMS for Direct Pre-Clinical Imaging of Drug Distribution and Metabolism
Katherine A. Kellersberger1; Michael L. Easterling1; Santosh Kesari2; Claire M. Sauvageot2; Jeffrey N. Agar3; Nathalie Y.R. Agar4
1Bruker Daltonics, Inc., Billerica , MA; 2Dana Farber Cancer Institute, Harvard Med. School, Boston, MA; 3Brandeis University, Waltham, MA; 4Harvard Medical School, Neurosurgery, Boston, MA
Novel Aspect: Direct assessment of drug distribution, metabolism, and blood-brain barrier crossing in animal xenografts using a MALDI-FTMS-based platform for preclinical imaging.
Presentation No. 8 - Increasing the Success Rate of Quantitative LC-MS/MS Bioanalysis in a Discovery Environment
Garnet McRae
Sussex Research Laboratories, 100 Sussex Drive, Ottawa, Ontario, Canada
Novel Aspect: An approach to fast, accurate LC-MS/MS analysis in a discovery environment. The use of generic methods and useful tips for more difficult compounds combined with discovery-stage appropriate Standard and QC preparation and acceptance criteria help to increase the success rate of analysis the first time.
Presentation No. 9 - From Single Cells to Whole Body Sections: Multiscale Imaging of Phospholipids by MALDI MS
Pierre Chaurand1; Peggi Angel2; Richard M. Caprioli2
1Presently at University of Montreal, Canada 2Vanderbilt University, Nashville , TN
Novel Aspect: High resolution imaging MS of phospholipids from tissue sections down to cellular dimensions.
Presentation No. 10 - Development of a Metabolite Identification Workflow using MALDI-QTof and Multivariate Statistical Analysis
Andrew Baker1; Stephen Mcdonald1; Henry Y. Shion2
1Waters Corporation, Beverly, MA; 2Waters Corporation, Milford , MA
Novel Aspect: Implementation of MALDI-Q-Tof Mass Spectrometry with Orthogonal Partial Least Squares Discriminant Analysis (OPLS-DA) for in-vitro metabolite identification .
Presentation No. 11 - Systematic and Expanded Investigation of High and Unexpected Positive Deviation for QC Samples during GLP Incurred Samples Analysis by LC-MS/MS
Georges El-Kadissi; Mireille Nohra; Natasha Savoie; Ericka Franco; Véronik Gill; Milton Furtado; Chantal Menard; Mary Carbone; Fabio Garofolo
Algorithme Pharma Inc., Laval (Montreal), Quebec , CANADA
Novel Aspect: Importance of structured investigation by using of multiple reference standards to explain the salient high deviation for quality control samples.
Presentation No. 12 - A simple way to remove phospholipids from bioanalytical samples
Ben Yong1; David Jones1; Ritu Arora1, Paul Boguszewski2
1Varian, Inc., Lake Forest , CA, 2Varian, Inc., Essex Road, Church Stretton, UK
Novel Aspect: Phospholipid removal from protein precipitation in a 96 well plate.
Presentation No. 13 - Evaluation of a New Electrospray Ion Source and Interface Combination for Ruggedness and Sensitive in LC-MS/MS
George Scott; Dragan Vuckovic; Charles Jolliffe
Ionics Mass Spectrometry Group, Bolton, ON, Canada
Novel Aspect: The new method of transporting ions into a MS minimizes optimization procedure, prevents instrument contamination, and increases the sensitivity.
Presentation No. 14 - A Comparison between Traditional Liquid-liquid Extraction (LLE) and Supported Liquid Extraction (SLE) using LC-MS/MS Analysis in Terms of Phospholipid Removal and LoQ
Lee Williams,Elena Gairloch
Biotage GB Limited, Dyffryn Business Park, Ystrad Mynach, Mid Glamorgan, CF82 7RJ, UK; Biotage, 1725 Discovery Drive, Charlottesville, VA 22911, USA
Presentation No. 15 - Mass Defect Trigger IDA to improve selection of candidate ions for MSMS confirmation of metabolites from in-vivo samples
J.C. Yves Leblanc1; Eva Duchoslav1; Nic Bloomfield2
1MDS Analytical Technologies, Concord, On , Canada ; 2MDS Analytical Tech- Sciex, Concord, ON
Novel Aspect: Real Time Selection of Precursor Ion based on Mass Defect, More Selective Detection and Confirmation of Metabolite.
